By Celeste M. Todaro, Henry C. Vogel
A whole reference for fermentation engineers engaged in advertisement chemical and pharmaceutical creation, Fermentation and Biochemical Engineering Handbook emphasizes the operation, improvement and layout of producing tactics that use fermentation, separation and purification concepts. Contributing authors from businesses comparable to Merck, Eli Lilly, Amgen and Bristol-Myers Squibb spotlight the sensible facets of the processes-data assortment, scale-up parameters, gear choice, troubleshooting, and extra. in addition they offer appropriate views for the various sectors using fermentation thoughts, together with chemical, pharmaceutical, nutrition, and biofuels.
New fabric within the 3rd variation covers themes appropriate to fashionable recombinant telephone fermentation, mammalian mobilephone tradition, and biorefinery, making sure that the booklet will stay appropriate world wide. It uniquely demonstrates the relationships among the unreal tactics for small molecules comparable to lively parts, medicines and chemical substances, and the biotechnology of protein, vaccine, hormone, and antibiotic creation. This significant revision additionally comprises new fabric on membrane pervaporation applied sciences for biofuels and nanofiltration, and up to date advancements in instrumentation comparable to optical-based dissolved oxygen probes, capacitance-based tradition viability probes, and in situ real-time fermentation tracking with instant expertise. It addresses topical environmental concerns, together with using new (bio)technologies to regard and make the most of waste streams and bring renewable strength from wastewaters. concepts for bioremediation also are explained.
- Fully up to date to hide the most recent advances in recombinant mobilephone fermentation, mammalian mobile tradition and biorefinery, in addition to advancements in instrumentation
- Industrial members from prime worldwide businesses, together with Merck, Eli Lilly, Amgen, and Bristol-Myers Squibb
- Covers man made approaches for either small and massive molecules
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Extra resources for Fermentation and Biochemical Engineering Handbook
Many microorganisms can use a single organic compound to supply both carbon and energy needs. Others need a variable number of additional organic compounds as nutrients. These additional organic nutrients are called growth factors and have a purely biosynthetic function, being required as precursors of certain organic cell constituents that the organism is unable to synthesize. Most microorganisms that depend on organic carbon sources also require CO2 as a nutrient in very small amounts . 9 g/l.
An outstanding example of cell suspension culture in a pilot scale bioreactor (750 1) was the production of shikonins by Mitui Petrochemical Industries. In all these examples, various technologies have been used to improve the productivity of the metabolites. The technologies include: (i) selection of a high yielding cell strain, (ii) screening of the optimum culture condition for metabolite production, (iii) addition of precursor metabolites, (iv) immobilized cell culture, and (v) differentiated tissue and/or organ culture.
During catabolism, glucose, as an example, is converted to carbon dioxide, water and energy. Enzymes catalyze the conversion from complex to simpler sugars. Three major interrelated pathways control carbohydrate metabolism: À The Embden-Meyerhof pathway (EMP) À The Krebs or tricarboxylic acid cycle (TCA) À The pentose-phosphate pathway (PPP) In the EMP, glucose is anaerobically converted to pyruvic acid and on to either ethanol or lactic acid. From pyruvic acid it may also enter the oxidative TCA pathway.