BioMEMS : Science and Engineering Perspectives by Simona Badilescu

By Simona Badilescu

IntroductionIntroduction to BioMEMSApplication AreasIntersection of technological know-how and EngineeringEvolution of platforms according to SizeCommercialization, strength, and MarketSubstrate fabrics utilized in BioMEMS DevicesMetalsGlasses and CeramicsSilicon and Silicon-Based SurfacesPolymersBiopolymersOrganic Molecules (Functional teams) focused on the Formation of Self-Assembled MonolayersBiomolecules and complicated Biological Read more...

summary: IntroductionIntroduction to BioMEMSApplication AreasIntersection of technological know-how and EngineeringEvolution of structures according to SizeCommercialization, power, and MarketSubstrate fabrics utilized in BioMEMS DevicesMetalsGlasses and CeramicsSilicon and Silicon-Based SurfacesPolymersBiopolymersOrganic Molecules (Functional teams) all for the Formation of Self-Assembled MonolayersBiomolecules and intricate organic Entities: constitution and PropertiesAmino AcidsPolypeptides and ProteinsLipidsNucleotides and Nucleic AcidsCarbohydratesEnzymesCellsBacteria and VirusesEngineering of Bioactive SurfacesPl

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Different polymeric materials and fabrication processes have been developed in order to fabricate microfluidic devices. Thermoplastic, thermosetting, and elastomer materials have been tested for different microfluidic applications. In order to create microchannels with different polymers as the structural materials, technologies such as hot embossing, laser ablation, soft lithography, and injection molding have been developed. The key feature to obtain robust polymeric microfluidic devices is to obtain an effective seal between the structured layer and a cover plate.

Lab Chip 6:407–13. 17. Korivi, N. , Ajmera, P. K. 2009. Micropatterning of biocompatible materials. Paper presented at ICMEMS Conference, Madras, India. Substrate Materials Used in BioMEMS Devices REVIEW QUESTIONS 1. What are the most important properties of glass that make it suitable for microfluidic applications? Give an example of a silica-based oxide glass material. What is the typical composition of a bioactive glass? What are the advantages and disadvantages of the silicon-based materials for microfluidic applications?

M. 1990. Miniaturized chemical analysis systems: A novel concept for chemical sensing. Sensors Actuators B 1:244–48. 2. Harrison, D. , Fan, Z. , Effenhauser, C. , Manz, A. 1993. Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip. Science 261:895–96. 3. Arroyo, M. , Fernández, L. , Blanco, F. J. 2007. Novel all-polymer microfluidic devices monolithically integrated within metallic electrodes for SDS-CGE of proteins. J. Micromech. Microeng. 17:1289–98.

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